Eribulin
Administration
• Administered intravenously (IV, meaning through the veins), typically in a hospital setting or chemotherapy day unit.
• Different delivery methods, including cannulas, central lines, PICC lines, or implantable ports, are tailored to individual patient needs.
• Eribulin treatment involves multiple cycles administered every 21 days, with the drug administered on days 1 and 8 of each cycle.
• A multidisciplinary team, including a cancer doctor, chemotherapy nurse, and specialist pharmacist, oversees the administration.
• Before treatment, a blood sample is taken to ensure safe blood cell levels for chemotherapy.
• You may receive oral or IV drugs prior and after the infusion to prevent nausea.
• It is possible that a subcutaneous injection is required following each cycle. Given at home or at the clinic, it will help boost the immune system.
• Imaging is usually repeated every 2-3 cycles to determine the response.
• The number of cycles of treatment will depend on your tolerance to treatment and your response.
Potential Side Effects & Management
While treatment is being given:
• Allergic Reactions: Signs include feeling hot, itching, rash, dizziness, or swelling. Prompt identification and treatment are crucial.
Common Side Effects:
• Infection Risk: Given sarcoma treatments’ intensity, reduced white blood cell counts heighten infection risks, necessitating vigilance and timely medical intervention. If you have a fever over 38.3°C, you should advise your medical team or go to the emergency department.
• Bruising and Bleeding: Reduced platelets due to treatment can lead to easy bruising, nosebleeds, or blood in urine/stool. Platelet transfusion might be necessary.
• Anemia: Reduced red blood cells due to treatment can cause anemia. If severe, blood transfusion might be necessary.
• Nausea and Hair Loss: Managing these side effects can significantly impact quality of life during treatment.
• Loss of Appetite: Treatment can impact appetite temporarily. Dietary changes may be suggested.
• Diarrhea: Increased bowel activity; more common if you have a stoma.
• Constipation: inability to pass stools as often as usual. Management includes drinking a lot of fluids, increasing fiber consumption, light exercise, and in severe cases, laxatives may be prescribed.
• Headache, Muscle or Joint Pain: Post-treatment pain in head, muscles or joints may arise; notify your doctor for pain relief, especially if persistent.
• Liver Impact: Potential mild effects on liver function; regular blood tests will monitor liver performance.
• Numbness and tingling in hands and feet: This treatment can cause numbness, tingling, or pain in the hands or feet; inform your doctor for possible dose adjustments.
• Stomach Pain: Pain, bloating, indigestion, or discomfort in the abdomen. Your doctor can prescribe medications to alleviate these symptoms.
Less Common Side Effects:
• Effects on Kidneys and Liver: Blood tests monitor kidney and liver function. Maintain hydration and report any unusual symptoms like blood in the urine, difficulty to pee, etc.
• Sore Mouth & Throat: Treatment may cause sore mouth and throat which can potentially lead to mouth ulcers and increased risk of infection. Maintain oral hygiene; contact your healthcare team for mouthwash or medicines if needed.
• Sore and Red Palms, Soles: Palmar-plantar syndrome causes redness and peeling. Keep hands and feet cool, moisturize, and avoid tight-fitting items.
• Sore Eyes: Watery eyes and discomfort may occur, treated with prescribed eye drops; inform your doctor if redness develops (conjunctivitis).
• Skin Changes: Rash, sensitivity, discoloration; moisturizing and protective measures are recommended.
• Nail Changes: Slower nail growth, breakage, ridges, or discoloration may be experienced. Moisturize nails, keep them short, wear protective gloves.
• Effects on the Heart: Eribulin may occasionally lead to changes in your heart beat, typically resolving after treatment cessation, but if you experience rapid heartbeat, inform your doctor.
• Hot Flashes: This treatment may induce hot flushes and sweating, characterized by warmth and redness in the neck and face, followed by sweats and possible feelings of anxiety or irritability. Strategies such as wearing breathable clothing, adjusting room temperature, and consuming cold drinks can help alleviate these symptoms.
• Fluid build-up: Weight gain or swelling; improves after treatment.
• Effects on the Lungs: Notify your doctor of any respiratory symptoms like coughing or breathlessness.
Precautionary Measures for Sarcoma Patients
• Blood clot risk: Report symptoms like swelling, breathlessness, or sharp chest pain immediately.
• Communication: Always prioritize informing your healthcare team about ongoing sarcoma treatments, ensuring coordinated care and potential adjustments.
• Vaccinations: Sarcoma patients should be aware of vaccination recommendations, especially considering treatment impacts on immune responses.
• Sex and Contraception: This treatment may impact fertility; discuss and plan contraception strategies with your oncologists.
• Breastfeeding: Avoid while having treatment.
Understanding the details of this treatment, including its administration, potential side effects, and precautionary measures, empowers patients to actively participate in their care and optimize treatment outcomes. Always communicate openly with your healthcare team for personalized guidance and support.