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VDC/IE is a chemotherapy combination consisting of the drugs Vincristine, Doxorubicin, Cyclophosphamide, Ifosfamide, and Etoposide, used to treat Ewing sarcoma and soft tissue sarcoma. Understanding the intricacies of this treatment, including its administration, potential side effects, and precautionary measures, is essential for patients to actively engage in their care and enhance treatment outcomes.